# -*- coding:utf-8 -*-
#! python3
import win32ui
import win32api
from win32con import *
from pywin.mfc import window
class MyWnd(window.Wnd):
  def __init__ (self):
    window.Wnd.__init__(self,win32ui.CreateWnd())
    self._obj_.CreateWindowEx(WS_EX_CLIENTEDGE,                 win32ui.RegisterWndClass(0,0,COLOR_WINDOW+1),                 'www.jb51.net - MFC GUI',WS_OVERLAPPEDWINDOW,                 (10,10,800,500),None,0,None)
    submenu = win32ui.CreateMenu()
    menu = win32ui.CreateMenu()
    submenu.AppendMenu(MF_STRING,1051,'&Open')
    submenu.AppendMenu(MF_STRING,1052,'&Close')
    submenu.AppendMenu(MF_STRING,1053,'&Save')
    menu.AppendMenu(MF_STRING|MF_POPUP,submenu.GetHandle(),'&File')
    self._obj_.SetMenu(menu)
    self.HookCommand(self.MenuClick,1051)
    self.HookCommand(self.MenuClick,1052)
    self.HookCommand(self.MenuClick,1053)
  def OnClose(self):
    self.EndModalLoop(0)
  def MenuClick(self,lParam,wParam):
    if lParam == 1051:
      self.MessageBox('Open','Python',MB_OK)
    elif lParam == 1053:
      self.MessageBox('Sava','python',MB_OK)
    else:
      self.OnClose()
w = MyWnd()
w.ShowWindow()
w.UpdateWindow()
w.RunModalLoop(1)

pip install pypiwin32